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Strategies for replacing myocytes with induced pluripotent stem in clinical protocols
15 December 2011
Fumiyuki Hattori, Keiichi Fukuda
Abstract: Induced pluripotent stem (iPS) cells can be established via forced epigenetic reprogramming of various somatic cells and selection based on given criteria. Human iPS cells are preferred for ...
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Surgical strategies for type II diabetes
24 November 2011
Joseph R. Scalea, Matthew Cooper
Abstract: Diabetes mellitus type II (or type 2 diabetes; DM2) has multiple definitions but is generally considered to be a disease marked by insulin resistance and loss of β cell function that develop...
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Role of T cell–nuclear factor κB in transplantation
10 November 2011
Luciana L. Molinero, Maria-Luisa Alegre
Abstract: Nuclear factor (NF) κB is a pleiotropic transcription factor that is ubiquitously expressed. After transplantation of solid organs, NF-κB in the graft is activated within a few hours as a co...
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T-cell activation and transplantation tolerance
10 November 2011
Bhavana Priyadharshini, Dale L. Greiner, Michael A. Brehm
Abstract: Transplantation of allogeneic or “nonself” tissues stimulates a robust immune response leading to graft rejection, and therefore, most recipients of allogeneic organ transplants require the ...
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Pig islet for xenotransplantation in human: structural and physiological compatibility for human clinical application
14 October 2011
Denis Dufrane, Pierre Gianello
Abstract: Allogeneic islet transplantation has proven difficult because organ shortages are recurrent, several pancreas donors are often needed to treat one diabetic recipient, and the intrahepatic si...
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