Transplantation Reviews RSS feed: Current Issue. Transplantation Reviews contains state-of-the-art review articles on both clinical and experimental transplantation. The journal features invited articles by authorities in immunology , transplantation medicine and surgery. Benefits to authors We also provide many author benefits, such as free PDFs, a liberal copyright policy, special discounts on Elsevier publications and much more. Please click here for more information on our author services . Please see our Guide for Authors for information on article submission. If you require any further information or help, please visit our support pages: http://support.elsevier.com http://www.transplantationreviews.com/?rss=yesElsevier Inc.en Crown Copyright © 2013. Published by Elsevier Inc. All rights reserved. Transplantation Reviews0955-470X272April 2013 Crown Copyright © 2013. Published by Elsevier Inc. All rights reserved. healthpermissions@elsevier.comhttp://www.transplantationreviews.com/article/PIIS0955470X13000207/abstract?rss=yesThere is no conference or meeting, publication or presentation in the field of transplantation that does not involve data from a transplant registry. Transplantation practice has been particularly suited to national, regional, specialist and global registries of the events marked by the removal of a living organ from one human being to another. It has been critically important to the development of success in transplantation that the data are accumulated from a large number of programs since, with the exception of a very limited number of centers, no single unit has the statistical power to describe anything but the commonest of outcomes. We have had to cooperate and collaborate to derive the information sufficient to understand what works better.EditorialJeremy Chapman10.1016/j.trre.2013.01.006Transplantation Reviews 27, 2 (2013)2013-03-01Transplantation Reviews2013-03-01272S0955-470X(13)X0002-3Editorial3737http://www.transplantationreviews.com/article/PIIS0955470X13000165/abstract?rss=yesAbstract: The International Registry for Heart and Lung Transplantation (Registry) was established by the International Society for Heart and Lung Transplant (ISHLT) in 1983. It has since become the largest repository of heart and lung transplant data in the world. The continued relevance of the Registry and its high impact scientific contributions have been possible through accountability and responsible governance. This manuscript describes the logistics of the Registry's operations, its goals and future directions.ISHLT International Registry for Heart and Lung Transplantation — three decades of scientific contributionsJosef Stehlik, Leah B. Edwards, Amanda Rowe, Kathryn Philibin, Jaime Williamson, James K. Kirklin, David O. Taylor, Marshall I. Hertz10.1016/j.trre.2013.01.005Transplantation Reviews 27, 2 (2013)2013-02-27Transplantation Reviews2013-02-27272S0955-470X(13)X0002-33842http://www.transplantationreviews.com/article/PIIS0955470X13000153/abstract?rss=yesAbstract: The Collaborative Transplant Study (CTS) was initiated in 1982. Over the last 30 years, it has collected information on over half a million kidney, liver, heart, lung, and pancreas transplant procedures. Participation is voluntary and the study has strictly scientific objectives. Analyses of the CTS database serve as an international reference source in the field of solid organ transplantation.The collaborative transplant study registryGerhard Opelz, Bernd Döhler, Andrea Ruhenstroth, Sofia Cinca, Christian Unterrainer, Lilli Stricker, Sabine Scherer, Petra Gombos, Caner Süsal, Volker Daniel, Hien Tran10.1016/j.trre.2013.01.004Transplantation Reviews 27, 2 (2013)2013-03-06Transplantation Reviews2013-03-06272S0955-470X(13)X0002-34345http://www.transplantationreviews.com/article/PIIS0955470X13000141/abstract?rss=yesAbstract: Transplant registries are a proven valuable source of data about transplantation. The inclusion of all transplants conducted in a region or country provides a different perspective from that of other observational studies. They allow examination of activity levels and trends, provide descriptions of outcomes which avoid the selection bias inherent in randomized clinical trials and facilitate hypothesis-generating studies. Examination of rare or unusual diseases and their outcomes is another area of strength.The models and structures of registries vary throughout the world. In Australia and New Zealand, kidney transplant outcomes are combined with dialysis in the Australia and New Zealand Dialysis and Transplant (ANZDATA) Registry. Deceased solid-organ donor activity is recorded in the Australia and New Zealand Organ Donor (ANZOD) Registry. Both of these registries are conducted and governed along similar lines. Key factors include strong clinical links in data collection and governance, and the involvement of contributors in a wide variety of activities and output.Australian registries—ANZDATA and ANZODStephen P. McDonald, Graeme R. Russ10.1016/j.trre.2013.01.003Transplantation Reviews 27, 2 (2013)2013-04-01Transplantation Reviews2013-04-01272S0955-470X(13)X0002-34649http://www.transplantationreviews.com/article/PIIS0955470X1300013X/abstract?rss=yesAbstract: Founded in 1987, the Scientific Registry of Transplant Recipients (SRTR) operates under a contract from the US government administered by the Health Resources and Services Administration (HRSA). SRTR maintains a database of comprehensive information on all solid organ transplantation in the US. The registry supports the ongoing evaluation of the clinical status of solid organ transplantation, including kidney, heart, liver, lung, intestine, pancreas, and multi-organ transplants. Data in the registry are from multiple sources, but most are collected by the Organ Procurement and Transplantation Network (OPTN) from hospitals, organ procurement organizations, and immunology laboratories. The data include information on current and past organ donors, transplant candidates, transplant recipients, transplant outcomes, and outcomes of living donors. SRTR uses these data to create reports and analyses for HRSA, OPTN committees that make organ allocation policy, and the Centers for Medicare & Medicaid Services to carry out quality assurance surveillance activities; SRTR also creates standard analysis files for scientific investigators. In addition, SRTR and OPTN produce an Annual Data Report and provide information upon request for the general public. Thus, SRTR supports the transplant community with information services and statistical analyses to improve patient access to and outcomes of organ transplant.Scientific Registry of Transplant Recipients: Collecting, analyzing, and reporting data on transplantation in the United StatesSusan Leppke, Tabitha Leighton, David Zaun, Shu-Cheng Chen, Melissa Skeans, Ajay K. Israni, Jon J. Snyder, Bertram L. Kasiske10.1016/j.trre.2013.01.002Transplantation Reviews 27, 2 (2013)2013-03-07Transplantation Reviews2013-03-07272S0955-470X(13)X0002-35056http://www.transplantationreviews.com/article/PIIS0955470X13000128/abstract?rss=yesAbstract: The Global Database on Donation and Transplantation represents the most comprehensive source to date of worldwide data concerning activities in organ donation and transplantation derived from official sources, as well as information on legal and organizational aspects. The objectives are to collect, analyse and disseminate this kind of information of the WHO Member States and to facilitate a network of focal persons in the field of transplantation. They are responsible for providing the legislative and organizational aspects and the annual activity practices through a specific questionnaire. 104 out of the 194 WHO Member States that cover the 90% of the global population contribute to this project.Although we know the numerous limitations and biases as a result of the different interpretations of the questions, based on cultural factors and language, there is no other similar approach to collect information on donation and transplantation practices all over the world. The knowledge of demand for transplantation, availability of deceased and living donor organs and the access to transplantation is essential to monitor global trends in transplantation needs and donor organ availability. Information regarding the existence of regulatory oversight is fundamental to ensure the ethical practice of organ donation and transplantation.Global Database on donation and transplantation: Goals, methods and critical issues (www.transplant-observatory.org)Beatriz Mahillo, Mar Carmona, Marina Álvarez, Luc Noel, Rafael Matesanz10.1016/j.trre.2013.01.001Transplantation Reviews 27, 2 (2013)2013-03-14Transplantation Reviews2013-03-14272S0955-470X(13)X0002-35760http://www.transplantationreviews.com/article/PIIS0955470X13000219/abstract?rss=yesAbstract: One of the most significant advances in the field of immunology in the last decade is delineation of the pivotal role of regulatory T cells (Tregs) in the maintenance of self-tolerance. While Tregs are just now being applied therapeutically in early phase clinical trials, data gleaned from basic and translational studies to-date suggest enormous potential to intervene in human disease. Data from our work and the work of others suggest that the innate immune system plays an important role in the differentiation and function of Tregs, largely through the production of cytokines but also through expression of cell surface ligands. These molecules are expressed differentially depending on whether the stimulus includes trauma, ischemia/necrosis, and microbial infection, and have opposing effects on Tregs, in contrast to those associated with dendritic cell maturation and somatic cell apoptosis, which promote Treg differentiation and function. We refer to the former process as Treg counter-regulation. Since the transplantation procedure involves surgical trauma, organ ischemia, and exposure to environmental microbes, Treg counter-regulation represents a key area of intervention to improve strategies for promoting allograft tolerance.Mechanisms of regulatory T cell counter-regulation by innate immunityHeidi Yeh, Daniel J. Moore, James F. Markmann, James I. Kim10.1016/j.trre.2013.02.001Transplantation Reviews 27, 2 (2013)2013-03-07Transplantation Reviews2013-03-07272S0955-470X(13)X0002-36164http://www.transplantationreviews.com/article/PIIS0955470X13000232/abstract?rss=yesSubscription prices10.1016/S0955-470X(13)00023-2Transplantation Reviews 27, 2 (2013)2013-04-01Transplantation Reviews2013-04-01272S0955-470X(13)X0002-3FrontmatterA1A1http://www.transplantationreviews.com/article/PIIS0955470X13000244/abstract?rss=yesEditorial Board10.1016/S0955-470X(13)00024-4Transplantation Reviews 27, 2 (2013)2013-04-01Transplantation Reviews2013-04-01272S0955-470X(13)X0002-3FrontmatterA2A2http://www.transplantationreviews.com/article/PIIS0955470X13000256/abstract?rss=yesTable of Contents10.1016/S0955-470X(13)00025-6Transplantation Reviews 27, 2 (2013)2013-04-01Transplantation Reviews2013-04-01272S0955-470X(13)X0002-3FrontmatterA3A3http://www.transplantationreviews.com/article/PIIS0955470X13000268/abstract?rss=yesInstructions for Authors10.1016/S0955-470X(13)00026-8Transplantation Reviews 27, 2 (2013)2013-04-01Transplantation Reviews2013-04-01272S0955-470X(13)X0002-3FrontmatterA4A5http://www.transplantationreviews.com/article/PIIS0955470X1300027X/abstract?rss=yesPrevious Issue10.1016/S0955-470X(13)00027-XTransplantation Reviews 27, 2 (2013)2013-04-01Transplantation Reviews2013-04-01272S0955-470X(13)X0002-3FrontmatterA6A6